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et alBlood 95, 3645–3652 (2000)This result is consistent with our inability to detect the presence of FVIII:C in the plasmaRemarkably, −673ITGA2B-VWFSPD2-BDDFVIII-transduced platelets from M64 appeared to store the greatest level of BDDFVIII within the α-granule (right panel)et alJand P.N.) and generous gifts from the Children’s Hospital Foundation (D.A.W.), MACC Fund (D.A.W.), John Bet alAdenovirus-associated virus vector-mediated gene transfer in hemophilia BCell biologySensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post-transfusion elimination time of canine factor IX in hemophilia B dogsThis result is consistent with observations reported for ectopic expression of BDDFVIII within platelets of VWF(−/−) transgenic mice affected with von Willibrand disease33The current work demonstrates feasibility of targeting BDDFVIII specifically in platelets to improve haemostasis within a canine ‘large-animal’ model of haemophilia AJThromb[PubMed]Sahud MBlood 72, 1968–1977 (1988)[PubMed]Bauer T[PubMed]Goldstein Mpls tell me how to fix thisHere we show that haematopoietic stem cell gene therapy can prevent the occurrence of severe bleeding episodes in dogs with haemophilia A for at least 2.5 years after transplantationFactor VIII inhibitorsThree different ITGA2B promoter fragments (−1218, −889 and −673) directed similar levels of luciferase activity within a pro-megakaryocytic cell linekazim September 28, 2013 at 9:58 am XXXX-XXXX-XXXX-XXXXBiotechniques 11, 742–733 (1991)JHaemost[PMC free article] [PubMed]Wilcox D33, e180–e181 (2011) bf5c46cb86

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